vaziri.rockefeller.eduVaziri Lab – Laboratory of Neurotechnology and Biophysics

News Research Optical Neurotechnology Mesoscale volumetric light-field (MesoLF) imaging of neuroactivity across cortical areas at 18 Hz High-Speed, Cortex-Wide Volumetric Recording of Neuroactivity at Cellular Resolution Using Light Beads Microscopy Volumetric C A 2+ Imaging in the Mouse Brain using Hybrid Multiplexed Sculpted Light (HyMS) Microscopy High-speed volumetric imaging of neuronal activity in freely moving rodents Brain-wide 3D light-field imaging of neuronal activity with speckle-enhanced resolution High-speed computational imaging, deep in scattering brain tissue using Seeded Iterative Demixing (SID) Microscopy Fast volumetric calcium imaging across multiple cortical layers using sculpted light Simultaneous Whole-Brain Functional Imaging of Neuronal Activity using Light-Field Microscopy Hybrid Light-Sculpting-Scanning for Versatile High-Speed Calcium Imaging High-Speed Brain wide 3D Calcium Imaging of Neuronal Activity with Sculpted Light Ultrafast Widefield Optical Sectioning Microscopy Single Neuron Specific Optogenetic Control Neuroscience Unbounded scaling of dimensionality with neuron number Neuronal basis of decision making at the single trial level Molecular mechanism underlying parallel microtubule bundle formation Direct detection of a single photon by humans IR-spectroscopy of KcsA Binding States Optical Force Spectroscopy Other Optical Tools Direct detection of a single photon by humans Optical Force Spectroscopy Multilayer Three-Dimensional Super-Resolution Microscopy People Publications Peer-reviewed In the media Resources Technologies Galleries Teaching Events Positions Contact Light Beads Microscopy Volumetric Ca 2+ imaging of 1 million neurons across the mouse cortex at cellular resolution using Light Beads Microscopy (LBM) FEATURED PUBLICATION Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level Neurotechnology and Biophysics Novel optical methods for generating functional maps of whole brain neuronal networks Light Beads Microscopy Volumetric Ca 2+ imaging of 1 million neurons across the mouse cortex at cellular resolution using Light Beads Microscopy (LBM) FEATURED PUBLICATION Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level Neurotechnology and Biophysics Novel optical methods for generating functional maps of whole brain neuronal networks Latest News Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need” in Science April 18, 2024 We are excited to share that our paper entitled "Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need" has been published in Science.Drugs of abuse produce pleasur... Read More We Welcome Our New Postdoc Nikita Kulachenkov March 26, 2024 Nikita received his Ph.D. in Physics and Mathematics from ITMO University, St. Petersburg, Russia where he worked on structure related optical switching in metal-organic frameworks. Most no... Read More New Article on bioRxiv: Whole-brain neural substrates of behavioral variability in the larval zebrafish” March 7, 2024 We are happy to announce that a new manuscript entitled Whole-brain neural substrates of behavioral variability in the larval zebrafish” has been uploaded to the bioRxiv preprint serve... Read More Research Welcome to the Vaziri Lab at The Rocke feller University . Our lab is also part of the Kavli Neural Systems Institute at The Rockefeller University. The central focus of our lab is the development and application of new optical imaging technologies for large-scale, high-speed, and single-cell resolution interrogation of neuroactivity with the goal of advancing our systems-level understanding of brain function. Many brain functions are emergent functional states of highly distributed functional networks that include the dynamic interaction of local circuits with long-range neuronal connections. However, the ability to detect and manipulate such large-scale functional circuits has been hampered by the lack of appropriate tools that allow parallel and spatiotemporally specific manipulation of neuronal population activity while capturing the dynamic activity of the entire network at high spatial and temporal resolution. To address this need, over the last decade, we have consistently pushed the limits on speed, volume size, and depth at which large-scale and whole-brain neuronal population activity can be optically recorded at cellular resolution, by pioneering a portfolio of new optical neurotechnologies. These include whole-brain calcium imaging in C. elegans ( Schrödel et al., 2013 ) and larval zebrafish ( Prevedel et al., 2014 ), high-speed volumetric imaging of neuroactivity within a mouse cortical column as well as sub-cortical calcium imaging ( Weisenburger et al., 2019 ), and most recently, in vivo volumetric cortex-wide recoding of up to one million neurons in the mouse brain ( Demas et al., 2021 ). Using these optical tools in context of specific biological questions in our own lab as well as in collaborative projects, we are interested in uncovering the information-theoretical and computational principles of how sensory information is represented at different levels processing across the mammalian brain and how its interaction with internal states generates behavior. We take a multidisciplinary approach, with our research areas and technology development drawing on different fields including physics, optics and optical engineering, systems neuroscience, and computation. Our current projects broadly fall into these following areas: Optical Neurotechnology Neuroscience & Biophysics Other Optical Tools Positions available in the Vaziri Lab JOIN US The Rockefeller University Vaziri Laboratory 1230 York Avenue New York, NY 10065 United States WordPress Theme - Total by...